Multistage Forward Path Regenerative Genetic Algorithm for Brain Magnetic Resonant Imaging Registration.

In image registration, the search space used to compute the optimal transformation between the images depends on the group of pixels in the vicinity. Favorable results can be achieved by significantly increasing the number of neighboring pixels in the search space; however, this strategy increases the computational load, thus making it challenging to realize the most desirable solution in a reasonable amount of time. To address the mentioned problem, the genetic algorithm is used to find the optimum solution and the solution lies in finding the best chromosomes. In rigid image registration problem, chromosomes contain a set of three parameters, x-translation, y-translation, and rotation. The genetic algorithm iteratively improves chromosomes from generation to generation and selects the best one having the best fittest value. Chromosomes with high fitness value are the ones with an optimal solution where the template image best aligns reference image. Fitness function in the genetic algorithm for image registration problem uses similarity measure index measure to find the amount of similarity between two images. The best fittest value is the one with a high similarity measure that shows the best-aligned template and reference image. Here we used the structural similarity index measure in fitness function that helps in evaluating the best chromosome, even for the compressed images with low quality, intensity nonuniformity (INU), and noise degradation. Building on the genetic algorithm, we propose a novel approach called multistage forward path regenerative genetic algorithm (MFRGA), abbreviated as MFRGA, with reducing search space at each stage. Compared with the single stage of genetic algorithm, our approach proved to be more reliable and accurate in terms of finding true rigid image transformation for alignment. At each increasing stage of MFRGA, results are computed with decreasing search space and increasing precision levels. Moreover, to prove the robustness of our algorithm, we utilized compressed images of brain magnetic resonant imaging that vary in compression qualities ranging from 10 to 100. Furthermore, we added noise levels of 1%, 3%, 5%, 7%, and 9% with an INU of 20% and 40%, respectively, provided by the online BrainWeb simulator. We achieved the monomodal rigid image registration that proves to be successful using MFRGA, even when the noise is critical, the compression quality is the least, and the intensity is nonuniform.