Impact of Smoking on Anal Abscess and Anal Fistula Diseases

: 吸烟对肛周脓肿及肛瘘疾病的影响摘要背景：目前，吸烟与肛周脓肿、肛瘘疾病的关系尚不明确。本文的目的是在中国男性人群中探讨吸烟对肛周脓肿、肛瘘疾病的影响。 方法：本文为回顾性研究，对2017年7月–2017年9月期间在中日医院肛肠科进行手术的所有男性患者进行电话回访，收集吸烟情况。病例组为患有肛周脓肿、肛瘘的患者，对照组为患有肛肠科其它疾病的患者。应用曼-惠特尼U检验和卡方检验分析组间差异，多因素回归分析潜在的影响因素。 结果：在排除能引起感染的炎症性疾病、糖尿病后，本研究共纳入977名18–80岁男性患者。其中805人（82.4%）完成问卷，病例组为334 (41.5%)人，对照组为471 (58.5%)人。结果显示，病例组与对照组患者在吸烟方面有显著差异 (OR: 12.331,95% CI: 8.364–18.179, P <0.001)，提示吸烟与肛周脓肿、肛瘘具有相关性。 结论：本研究提出在中国人群中吸烟是肛周脓肿、肛瘘疾病的潜在危险因素。因此，对患有肛周脓肿、肛瘘疾病的吸烟者应告知吸烟产生的此影响。同时，亦需要开展进一步地研究以深入揭示两者关系。. Methods: In this retrospective study, a questionnaire, including smoking history, was completed over a 3-month period by male inpatients in the Proctology Department of China-Japan Friendship Hospital. "Cases" were patients who had AA/F, and "controls" were patients with other anorectal complaints. Mann-Whitney U-test and Chi-square test were carried out to examine differences in baseline characteristics between groups. Subsequently, multivariate logistic regression was used to explore any related factors. Results: A total of 977 patients aged from 18 to 80 years were included, excluding those diagnosed with inflammatory bowel disease or diabetes mellitus. Out of this total, 805 patients (82.4%) completed the entire questionnaire. Among the 805 patients, 334 (41.5%) were cases and 471 (58.5%) were controls. Results showed significant differences between cases and controls (χ2 = 205.2, P < 0.001), with smoking found to be associated with the development of AA/F diseases (odds ratio: 12.331, 95% confidence interval: 8.364-18.179, P < 0.001). Conclusions: This study suggested smoking to be a potential risk factor for the development of AA/F diseases in a Chinese population. Consequently, current smoking patients should be informed of this relationship, and further research should be conducted to explore and investigate this further.