Microfluidic Cell Lysis Device for Point of Care Diagnostics

Author(s): Chavarin, Andrew; Espitia, Leovi; Khan, Saffi; Lopez, Marisa; Norpetlian, Frederique; Tarif, Abdullaah | Abstract: BackgroundPoint-of-care (POC) diagnostics provide quick results for patients in remote areas with limited access to laboratory equipment. Concurrently in-vitro diagnostic device market is a valued at $24 billion dollar and its expected to be valued at over $70 billion by 2020 • These diagnostics require access to intracellular components, such as DNA, which can be accessed by bursting open the cell, a process called cell lysis. Microfluidic technology allows for an entire laboratory procedure to miniaturized onto a small, portable platform, allowing for a quicker diagnostics and results. Andrew Chavarin, Leovi Espitia, Saffi Khan, Marisa Lopez, Frederique Norpetlian, Abdullaah TarifAdvisor: Professor William C. TangMentor: Dr. Brad Sargent, Omnica Corporation, Irvine, CASchool of EngineeringDepartment of: Biomedical Engineering, Chemical and Material Science a Mechanical and Aerospace Engineering,University of California-Irvine, CA