Web Servers for the Prediction of Curvature as well as other DNA Characteristics from Sequence

As very large amounts of genomic sequence data are generated, there is a growing need for simple methods that can guide experimenters to find regions that are conspicuous in terms of some structural properties, such as flexibility or intrinsic curvature. Over the past years we have been interested in developing and testing simple mechanic models that can describe the local behaviour of DNA in such short segments, in a sequence dependent fashion. These methods have been incorporated into WWW-based server programs located on the ICGEB web site and the calculations have been extended to the calculation and visualization of various parameters other than curvature.