Novel pyridine-2,4,6-tricarbohydrazide derivatives: Design, synthesis, characterization and in vitro biological evaluation as α- and β-glucosidase inhibitors

Abstract A range of novel pyridine 2,4,6-tricarbohydrazide derivatives (4a – 4h) were synthesized and its biological inhibition towards α- and β-glucosidases was studied. Most of the compounds demonstrate to be active against α-glucosidase, and quite inactive/completely inactive against β-glucosidase. A number of compounds were found to be more active against α-glucosidase than the reference compound acarbose (IC 50 38.25 ± 0.12 μM); being compound 4d with the p -hydroxy phenyl motive the most active (IC 50 20.24 ± 0.72 μM). Molecular modeling studies show the interactions of compound 4d with the active site of target α-glucosidase kinase.