Infection and immunity toPseudomonas
1991
Chronic pulmonary infection withP. aeruginosa in CF may result from:
1.
An initial failure of clearance mechanisms (increased adherence) leading to the development of a highly compartmentalized inflammatory reaction;
2.
Inhibition of clearing mechanisms for bacteria present in the bronchial lumen; and
3.
A largely ineffective, and possibly damaging, hyperactivity of inflammatory cells in the lumen and bronchial wall.
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