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Conflict of interest statement PD Dr. Mackensen has served as a paid consultant for Merck Serono and has received payment for continuing medical education events from Heidelberg Engineering. PD Dr. Ness has served as a paid consultant for Abbvie. He has received reimbursement of meeting participation fees and travel and accommodation expenses from Bayer Health Care, as well as payment for continuing medical education events form Abbvie and Novartis and for the performance of clinical trials on behalf of Novartis, Santen, Abbvie, Sanofi, Allergan, and pSivida corp.