Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-mediated Mechanism.

Jie Shao,Chun-Hua Huang,Bo Shao,Li Qin,Dan Xu,Feng Li,Na Qu,Lin-Na Xie,Balaraman Kalyanaraman,Ben-Zhan Zhu

Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-mediated Mechanism.

2020

Jie Shao
Chun-Hua Huang
Bo Shao
Li Qin
Dan Xu
Feng Li
Na Qu
Lin-Na Xie
Balaraman Kalyanaraman
Ben-Zhan Zhu

Halogenated quinones are a class of carcinogenic intermediates and newly identified chlorination disinfection byproducts in drinking water. We found recently that halogenated quinones could enhance...

Keywords:

Haloquinone
Environmental science
Organic chemistry
Inorganic chemistry
DNA
Carcinogen

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