Correlation of serum biochemical characteristics with its gallstone compositions

Gallstone disease is usually an asymptomatic disease affecting millions of people all over the world. It is also considered as the most important risk factor for developing gallbladder cancer. Gallstone is found in populations in most parts of the world, while its existence is prevalent in certain regions like India, Chile, Japan and USA. Analysis of gallstone and biochemical characteristics of patient may provide the important insights to pathophysiology of gallstone disease. For this purpose, nuclear magnetic resonance (NMR) spectroscopy was applied for the compositional analysis of gallstone. Later, the observational study was carried out by comparing the composition of gallstone along with specific biochemical characters of gallstone patients. On the basis of present study, it was revealed that the gallstone disease mainly affected the late youth and early middle-aged persons. It was also found that women are at a higher risk than men. Majority of patients had derangement of liver functions as well as derangement of lipid profile. An association between serum bilirubin and cholesterol levels was found in our study. The findings of present study showed that cholesterol is the most common component in gallstone and amount of cholesterol in gallstone was associated with serum bilirubin levels and dyslipidaemia. Obesity, non-vegetarian diet and increased levels of were possible etiological risk factors warranting lifestyle and dietary modification as a possible preventive measure.