Assessment of left ventricular mechanical dyssynchrony in patients with end-stage renal disease

1830 Objectives The presence, severity, and extent of left ventricular mechanical dyssynchrony (LVMD) have not been fully clarified in patients with end-stage renal disease (ESRD). Abnormal loading has capability to enhance Left ventricular mechanical dyssynchrony (LVMD) in patients with ESRD. The aim of this study was to assess the severity of LVMD and its relation to systolic function in ESRD. Methods A total of 219 patients (age 69 ± 10, 156 men) with chronic kidney disease (CKD) underwent stress/rest gated myocardial perfusion SPECT (GMPS). For the evaluation of LVMD, histogram bandwidth (HBW) and phase standard deviation (PSD) were determined by GMPS using phase analysis. LVMD was compared among three groups without ischemia (SSS > 3): 42 patients with CKD stage1 and 2, 54 patients with CKD stage 3 and 4, and 10 patients with CKD stage 5 defined as ESRD. Results Both HBW and PSD was significant negative correlated with LVEF in all 106 patients without ischemia. HBW in ESRD were significantly greater than those of CKD stage 1-2 and 3-4 (ESRD vs. CKD 1-2, p Conclusions LVMD was demonstrated to be enhancement in ESRD