Effect of mexamine on arterial tonus in dogs

: The effect of mexamin (5 and 10 mg/kg) on the vascular tone of thoracic and abdominal cavity vessels and pelvic limbs was investigated by angiography in experiments on 19 mongrel dogs under nembutal anesthesia (30 mg/kg). 5-7 minutes after intramuscular administration of the drug there was a constriction of the aorta, of the hepatic, splenic, cranial mesenteric, internal and external iliac, branched femoral and tibial arteries by about 15-40% as compared to the initial diameter. Mexamin exerted no substantial vasoconstrictive action on the segmental (intercostal, lumbar, phrenoabdominal) and renal arteries.