Evaluating Bronchodilator Effects in Chronic Obstructive Pulmonary Disease using Diffusion-Weighted Hyperpolarized Helium-3 Magnetic Resonance Imaging

The objective of this study was to evaluate the regional effects of bronchodilator administration in chronic obstructive pulmonary disease (COPD) using hyperpolarized helium-3 (3He) MRI apparent diffusion coefficient (ADC). Ten COPD ex-smokers provided written, informed consent and underwent diffusion-weighted, hyperpolarized 3He MRI, spirometry, and plethysmography before and 25 ± 2 min after bronchodilator administration. Pre- and postsalbutamol whole-lung (WL) ADC maps were generated and registered together to identify the lung regions containing the 3He signal at both time points, and mean ADC within those regions of interest (ROI) was determined for a measurement of previously ventilated ROI ADC (ADCP). Lung ROI with 3He signal at both time points was used as a binary mask on postsalbutamol WL ADC maps to obtain an ADC measurement for newly ventilated ROI (ADCN). Postsalbutamol, no significant differences were detected in WL ADC (P = 0.516). There were no significant differences between ADCN and ADCP...