Aluminum and Silica Containing Porous Carrier for Active Pharmaceutical Ingredients

Data on synthesis and research of physical and chemical and biological properties meso - macroporous carriers of different particle size distribution (0.1 mm and 0.2-0.8 mm) on the basis of mechanically strong porous oxide of aluminum ( $\gamma-\mathrm{A}1_{2}0_{3}$ ) and silica polymer (polydimethylsiloxane) are provided in this study. The carriers (white color) received at temperatures up to 200°C have the hydrophilic and hydrophobic nature of a surface and size of a specific surface to 200 m2/g. Adsorptive properties of carriers are estimated: on dye of methylene blue 5.5 mg/g (for particles with size 0.1 mm) and 6.9 mg/g (for particles with size 0.2-0.8 mm) and on B12 vitamin 0.6 mg/g for small and large size particles. It is shown, that carriers does not inhibit proliferative potential of human bone marrow mesenchymal stem cells and endothelial cell line EA.hy 926. Carriers are not toxic, it was not succeeded to define the LD50 on the basis of the carrier and lithium citrate (0.5%), not observed the death of animals at the doses, by 30-times exceeding a therapeutic dose and no have observed chronic toxicity (in rabbits, and in rats). Carriers are perspective for creation of the drugs containing active ingredients, such as lithium, melatonin and silver.