Is the Extent of Coronary Artery Stenosis in Prediabetic Patients Similar to That in Diabetics

Background: Some studies have shown that prediabetes may be associated with a greater incidence of coronary artery disease (CAD). Since there is a conflict concerning the relationship between CAD and optimal glucose level, this study focused on the relationship between CAD in different groups of diabetes, prediabetes (impaired fasting glucose (IFG)), and normal through fasting blood glucose classification. Methods: This is a case-control study carried out on 98 patients in each group of prediabetes, diabetes, and normal glycemia referred to the coronary angiography clinics of Chamran and Khorshid hospitals in 2014. The multiple logistic regression tests were used for statistical analysis in SPSS, version 20. Results: Comparison of CAD between the groups showed a higher risk of CAD in the diabetic group than in the normal group (P<0.001, OR=2.314). Also a higher risk of CAD was found in the prediabetic group than in the normal group (P=0.001, OR=1.630). Conclusions: Our results provide further strong evidence that glucose evaluation should be a part of standard testing for the prevention of cardiovascular diseases. (Iranian Heart Journal 2016; 17(1): 38-44)