FRI0028 Gazing into the Crystal Ball? Prospective MRI Score to Predict Negative Eular-Response in Patients with Rheumatoid Arthritis (RA) Before Therapy-Escalation to a Biological Therapy

Objectives To define and validate a new MRI score for the prediction of negative response in patients with rheumatoid arthritis (RA) before therapy-escalation to a biological therapy. Methods Remission plus was a multicentre (n=11) German “real-life” MRI study with the aim to implement MRI in diagnostic and therapy-control in patients with RA. MRI was performed before therapy-escalation (T0) and after 12 month (T1) and were analysed by using the OMERACT rheumatoid arthritis MRI score (RAMRIS). In addition clinical and laboratory parameters (DAS-28 and CRP) were collected for each visit. The new MRI score was developed using a logistic regression and is a combination of the patients9 age and the RAMRIS-T0 score. In the logistic regression we adjusted for possible confounders. Performance of the score is assessed in terms of area-under-the-curve (AUC). To validate the new score, a bootstrap analysis is performed with 5000 resamplings. Results Overall 257 patients were investigated with MRI, while 29 (20 female, median age 57 (IQR 46 – 65) years, 95% anti-TNF-alpha therapy) of them were escalated to a biological therapy. Poor responders (n=5) and non-poor responders (n=24) had a mean RAMRIS-T0 score of 14.4 and 52.0, respectively (Wilcoxon test p Conclusions RAMRIS-T0 possibly has the potential to predict poor EULAR-response in patients with RA before initiation of a biological therapy. By using the new score the predictive value was (AUC up to 95%) surprisingly high. Due to its high predictive value this score could be a possible tool in personalized medicine concepts after performing follow-up studies in clinical trials. Disclosure of Interest None declared