Botulinum Toxin Therapy in Medical Pain Disorders

Animal studies have shown that local injection of botulinum neurotoxins (BoNTs) reduces neuropathic pain. This effect is exerted via interfering with the function of pain transmitters and modulators at peripheral and central levels. Recent studies in humans have demonstrated an analgesic effect in several pain disorders. In this chapter, the effect of BoNT therapy in different medical, human pain syndromes is reviewed. The level of efficacy in each pain syndrome is determined according to the guidelines of the Assessment Subcommittee of the American Academy of Neurology.