Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

Luciano G. Martelotto,Timour Baslan,Jude Kendall,Felipe C. Geyer,Kathleen A. Burke,Lee Spraggon,Salvatore Piscuoglio,Kalyani Chadalavada,Gouri Nanjangud,Charlotte K.Y. Ng,Pamela Moody,Sean DItalia,Linda Rodgers,Hilary Cox,Arnaud Da Cruz Paula,Asya Stepansky,Michail Schizas,Hannah Y. Wen,Tari A. King,Larry Norton,Britta Weigelt,James W. Hicks,Jorge S. Reis-Filho

Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples

2017

A method enabling copy-number analysis of single cells from formalin-fixed paraffin-embedded samples is described, validated and applied to analyze samples of synchronous ductal carcinoma in situ and invasive breast carcinoma.

Keywords:

Breast cancer
Ductal carcinoma
Cell
Invasive breast carcinoma
Genome
Whole genome sequencing
Pathology
Biology
In situ
Virology
Genomics
Cancer cell
Computational biology
Tumour heterogeneity
Genetic heterogeneity

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