Adenosquamous carcinoma of gallbladder presenting as chronic cholecystitis with cholelithiasis- a rare entity

Carcinoma of the gallbladder is the most common malignancy of the biliary tract. Although adenocarcinomas account for more than 90% of gallbladder cancers, the incidence of adenosquamous carcinomas (ASCs), a rare subtype of gallbladder cancer, accounts for 1.4-10.6% of all carcinoma incidences. ASCs have aggressive biological behavior due to their potential for direct extension into the liver and neighboring structures like stomach, duodenum, and transverse colon but lacks metastasis in lymph nodes or viscera. ASC of the gallbladder lacks specific clinical presentation until the tumor has grown substantially large in size, and the carcinoma is at advanced stages. Patient complains generally of pain right hypochondrium. At times, they may present rarely as cholecystitis. We report here a case of a adenosquamous carcinoma of the gallbladder in a 45-year-old female presenting unusually as chronic cholecystitis with cholelithiasis. Keywords: Adenosquamous, Carcinoma, Gallbladder, Cholecystitis