Susceptibility of hamsters and mice to Paracoccidioides brasiliensis using different routes of inoculation

Experiments were made to investigate the efficacy of inoculation of hamsters and mice by different routes, for the recovery of the mycelial phase ofParacoccidioides brasiliensis. A clear superiority was found for the intratesticular route in hamsters over the intraperitoneal route in the same animal and also over the intraperitoneal and intravenous routes in mice. The intratesticular route in hamsters is thought to be the most appropriate to be used in future attempts to isolateP. brasiliensis from nature.