Blood pressure variability and common risk factors of ischemic cerebrovascular disease in Guangzhou communities

Objective To analyze the blood pressure variability (BPV) and common risk factors of ischemic cerebrovascular disease (ICD) in Guangzhou communities. Methods From July, 2016 to December, 2017, 326 ICD inpatients from Guangzhou communities were collected, and compared with 113 patients in a control group. The risk factors between the ICD group and the control group were analyzed with the respects to the average systolic blood pressure (SBP), diastolic blood pressure (DBP) , BPV (including SBPV and DBPV on admission and in the first two mornings after admission as well as and other factors such as blood lipid, etc. Afterwards, the ICD group was further divided into a acute cerebral thrombosis (ACT) group and a transient ischemic attack (TIA) group to further compare the parameter differences between them. Results The SBPV (Z =4.662, P< 0.01), SBP (t =8.092, P< 0.01), DBP(t =6.653, P< 0.01) in the ICD group were higher than those in the control group. Logistic regression revealed that the onset of ICD was related to SBPV (OR = 342 497.33, P= 0.000), SBP (OR = 1.035, P = 0.000), and DBP (OR =1.040, P = 0.004). Additionally, compared to the TIA patients, the SBPV (Z =-2.013, P< 0.05), SBP (Z =-4.695, P< 0.05), and DBP (Z =-4.486, P< 0.05) of the ICD patients all raised. Moreover, the onset of ACT was as well related to SBPV (OR = 2 186.769, P = 0.032), SBP (OR = 1.025, P = 0.011), and DBP (OR =1.039, P = 0.016). Conclusions SBPV, Mean SBP, and DBP are risk factors not only for the onset of ICD, but also for ACT; and among them, SBPV is the most dangerous, and it may play an important role in the development of ACT. Key words: Blood pressure variability; Ischemic cerebrovascular disease; Cerebral thrombosis; Transient ischemic attack; Community research