The association of bullous pemphigoid and ulcerative colitis.

Bullous pemphigoid (BP) is an uncommon blistering skin disease, mainly affecting the elderly and often described in association with other autoimmune disorders (1–5). It has rarely been reported in association with IBD (2, 6–8). We report two patients with ulcerative colitis (UC) who developed BP at an age younger than that of the typical BP patient. Given the rarity of BP and the immune dysregulation common to both UC and BP, namely, a Th2 antibody response, we postulate a casual association of these disorders. Furthermore, BP could be considered an extraintestinal manifestation of IBD.