Microwave-Accelerated Dimroth Rearrangement for the Synthesis of 4-Anilino-6-nitroquinazolines. Application to an Efficient Synthesis of a Microtubule Destabilizing Agent.
2010
A variety of substituted anilines is applied to the reaction with cyanophenyl dimethylimidoformamide substrates (I) and (VIII) under microwave-assisted conditions and atmospheric pressure to afford the desired 4-anilinoquinazolines (III) or (IX).
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