Gastric Anti-ulcer Activity of Several α, β-Unsaturated Carbonyl Compounds in Rat

The gastric cytoprotective activity of several molecules containing an α, β-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the β carbon of the Michael acceptors of the compounds assayed.