Lateral flow biosensors

A typical lateral flow biosensor employs a sandwich detection system and uses tracer(s) to generate detectable signal(s) (Figure 13.1). However, recent advances in nanomaterials offer a wide variety of improvement options, including new detection methodologies, signal transformation and improvements in sensitivity and specificity [4-6]. In this chapter, we describe the basic lateral flow detection system, the major components and their functions, critical parameters for successful lateral flow detection, and applications in biosensing. We also point out the hurdles facing commercial development of lateral flow biosensors. In particular, we consider future perspectives of lateral flow biosensors for personalized onsite biomedical diagnosis. © The Institution of Engineering and Technology 2016.