Ultrastructural characteristics of endometrioid and serous ovarian adenocarcinomas

: Analysis of the fine structure of glandular-solid tumors of the ovaries of endometrioid and serous genesis was carried out for specification of criteria for differential diagnosis of these tumors. The specific ultrastructural features (homogeneous or heterogeneous cell composition, the presence or absence of villi, tonofibrilos, glycogen inclusions) were shown to be present in areas of formation of glandular structures. Diagnosis of solid variants of endometrioid and serous carcinomas should also take into consideration the rate of occurrence of such ultrastructural signs typical of malignant cells as deep invaginations of the nuclear membrane, extended perinuclear space, increased number of nucleoli and macrosegregation of their content, increased number of myelin figures, polymorphism of mitochondria, cut-up cellular surface, well-developed laminar complex, and hypertrophy of the cytoplasmic reticulum. In serous carcinomas these features occur much more frequently.