Effects of Aerobic Physical Training on Thermoregulatory Adjustments During Physical Exercise in Spontaneously Hypertensive Rats

This study aimed to investigate the effects of physical training on thermoregulatory adjustments during running exercise and its effects on brain neuronal nitric oxide synthase (n-NOS) expression. Male spontaneously hypertensive (SHR) and normotensive Wistar rats (NWR) at 8-weeks age old were divided into four groups: untrained NWR (NWR-U), trained NWR (NWR-T), untrained SHR (SHR-U) and trained SHR (SHR-T). Experimental procedures were approved by the CEUA-UFMG (#21/2015). Aerobic exercise training was performed on a treadmill running for 8 weeks. On the day of the experiments, the rats were subjected to a constant-speed (60% of Vmax) protocol until fatigue at 25°C. Tail skin temperature (Ts) and abdominal temperature (Ta) were measured every minute throughout the exercise trials. The preoptic area (POA) and paraventricular nuclei (PVN) of hypothalamus was collected to quantification of n-NOS(ser852) by western blot. During exercise, the SHR-U group showed greater increase in Ta compared to with NWR-U gro...