POEMS (POlynEurOPA thy, OrgAnOMEgAly, EndOCrinOPA thy, M PrOtEin, Skin lESiOnS) SyndrOME
2007
The POEMS syndrome, also known as Crow-Fukase syndrome, is an unusual systemic dis - order described mainly in Asian individuals. It is characterized by the presence of (P)polyneuropathy, (O)organomegaly, (E)endocrinopathy, (M) M-protein, and (S) skin changes. Several other associated con - dictions such as sclerotic bone lesions, Castleman disease, low-grade fever, edema and hematologic disor - ders are usually seen. We describe five Brazilian patients with this syndrome. Two patients presented Cas - tleman disease, one patient presented osteosclerotic myeloma and in two patients no associated condi - tions were found.
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