Sentinel node biopsy using dye methods

At first, sentinel node identification was performed using dyes such as isosulfan blue dye and patent blue dye. Although dye localization is a simple and cheap method, this procedure requires training and the success rate and accuracy are not very good. It is considered that the addition of a radiocolloid injection is needed for sentinel node biopsy in melanoma and breast cancer. For gastrointestinal tract malignancies, good results were reported in several feasibility studies. However, the validity of sentinel node biopsy for those malignancies depends on the results of a large ongoing clinical trial.