Histone Acetylation and Disease

Acetylation of nucleosomal core histones plays a key regulatory role in many physiological processes such as proliferation and differentiation. Aberrant acetylation or deacetylation of histones leads to severe human diseases such as leukemia, epithelial cancers, fragile X-syndrome and Rubinstein–Taybi syndrome. Keywords: histone acetyltransferase; histone deacetylase; histone, chromatin; leukemia