Drug interactions with grapefruit
2010
Introduction. The concentration of many orally given medications may be
affected by grapefruit or grapefruit juice consumption. It may result in
numerous harmful effects. Interaction of grapefruit with drugs. Taking only
one cup of juice may induce interactions with different drugs even during the
period of a few days. The effect is induced by suppression of cytochrome P450
isoenzyme CYP3A4 in the intestinal wall. The Latin name of grapefruit, Citrus
paradisi, is quite opposite to the effects which could be induced by taking
grapefruit and some medications at the same time. It is necessary to avoid
taking grapefruit with the drugs whose pharmacokinetics could be altered by
the active principles found in that fruit. Discussion. The coloured
grapefruit contains less furanocoumarins, but there is no difference in
induction and intensity of pharmacokinetic interaction with drugs related to
its colour. Other citrus fruits (orange, lemon) do not have such effects, but
some other fruits (pomegranate, stella fruit, banpeiyu, hassaku,
takaoka-buntan and kinkan) exert inhibitory effects on the activity of
cytochrome P450 isoenzyme.
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