Clinical morphological characteristics of seminomas

: Two hundred patients with seminomas were under observation in the urological clinic of the N.N Petrov Research Institute of Oncology. The histological characteristic of 3 groups of seminomas is presented; spermatocytic seminomas (Masson seminoma)--in 9 patients, Chevassu seminomas (dysgerminomas)--in 95, and dysgerminomas with the syncytio-and cytotrophoblast elements--in 86. Observations over the patients indicated that Chevassu seminomas (dysgerminomas) metastases are highly sensitive to radiotherapy and sarcolysin, while Masson seminoma metastases and dysgerminomas with the trophoblast elements would show resistance to the therapy of this kind. The experience has shown that including of olivomycin and cyclophosphane in the chemotherapy for spermatocytic seminomas and of methatrexate and dactinomycin for dysgerminomas with the trophoblast elements enhances the effectiveness of the treatment. Also, it seems rational to include retroperitoneal lymphadnectomy in the complex of measures against dysgerminomas with the trophoblast elements.