Su1895 ERCP Contrast Induces NF-κB Activation Through Calcineurin and ER Stress in a Pancreatic AR42J Cell Line

infiltration, and interstitial edema were all reduced in cerulein-treated PKD3Δpanc mice compared to controls. Conclusion: PKD3Δpanc mice displayed significant attenuation in inflammation, acinar cell necrosis, and severity of pancreatitis. These novel findings indicate that this animal model can be used to demonstrate the role of PKD in the pathobiologic responses in the pancreatic acinar cell during pancreatitis.