Acute myocardial infarction in cocaine addicts

: The cases of 4 young patients (3 males, 1 female) addicts to cocaine with acute myocardial infarction is reported. In the first case, in a 28 year-old woman was found a multisystemic disorder with anterolateral myocardial infarction, acute renal failure, rhabdomyolysis and death. In the necropsy examination no atherosclerotic coronary lesions were found. In other two cases, was carried out coronary angiography, who revealed in one case normal angiographically coronary arteries, and in the other case, a 80% coronary narrowing in the proximal segment of the infarct-related coronary artery. We reviewed the cocaine-induced heart disease, and the pathophysiology of the acute myocardial infarction related to cocaine use.