Total Intravenous Anaesthesia with an Integrated Computer Control System

Abstract An integrated multivariable computer control system is currently under development to assist anaesthetists in the administration of anaesthetic, analgesic and muscle relaxant infusions for total intravenous anaesthesia This multivariable system is the integration of several single variable systems developed by the research team. A serimultiplexer, vas developed by the research team to allow communication of multiple infusion and monitoring devices via a single computer serial port. Initially the system was arranged with pharmacokinetic model-driven systems for the anaesthetic and analgesic agents and a Relaxograph (Datex) monitor was used for fuzzy closed-loop control of neuromuscular block (NMB).