Evaluation of nestin in lung adenocarcinoma: relation to VEGF and Bcl-2

AbstractContext: Nestin is a marker of multipotent precursor cells that is up regulated in cancer.Objective: To explore its diagnostic role and its relationship to vascular endothelial growth factor (VEGF) and Bcl-2 in lung adenocarcinoma.Materials and methods: Evaluation of nestin expression in lung biopsies by real-time PCR and serum VEGF and Bcl-2 by ELISA in 27 adenocarcinoma patients and 15 control subjects.Results: Nestin was significantly higher in lung adenocarcinoma patients especially with advanced grade and stage and it was significantly correlated to VEGF and Bcl-2.Conclusion: Nestin can be considered as a potential diagnostic marker in lung adenocarcinoma.