The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model

María del Mar García-Suárez,Noelia Flórez,Aurora Astudillo,Fernando Vázquez,Roberto Villaverde,Kevin Fabrizio,Liise-anne Pirofski,F. J. Méndez

The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model

2007

María del Mar García-Suárez
Noelia Flórez
Aurora Astudillo
Fernando Vázquez
Roberto Villaverde
Kevin Fabrizio
Liise-anne Pirofski
F. J. Méndez

Background Intranasal inoculation of Streptococcus pneumoniae D39 serotype 2 causes fatal pneumonia in mice. The cytotoxic and inflammatory properties of pneumolysin (PLY) have been implicated in the pathogenesis of pneumococcal pneumonia.

Keywords:

Serotype
Bronchoalveolar lavage
Immunology
Streptococcus pneumoniae
Cytotoxic T cell
Pneumolysin
Pathogenesis
Lung
Pneumococcal pneumonia
Medicine
Alveolar macrophage

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