5-fluorouracil drug eutectic crystal and preparation method thereof

2014 
The invention discloses novel 5-fluorouracil drug eutectic crystal and a preparation method thereof. 5-fluorouracil bulk drug is selected and used as drug API; selected and used drug precursor is para aminobenzoic acid; the prepared 5-fluorouracil drug eutectic crystal is anorthic system; the axial length is as shown in the specification. The novel eutectic structure prepared by the preparation method can effectively modify active ingredients of the drug; the para aminobenzoic acid forms eutectic crystal through hydrogen bond, and cannot form other bonds with water or other external interference, so that the effect that the drug is more stable is played; the eutectic crystal is prepared according to an ordinary temperature solvent slow evolution method; the method is simple, convenient and feasible to operate, convenient to widely popularize in industrial pharmaceutical manufacturing, and low in cost.
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