Bausteine für Oligonucleotid-Synthesen mit einheitlich fragmentierbaren β-halogenierten Schutzgruppen /Building Blocks for Oligonucleotide Syntheses with Uniformly Fragmentable β-Halogenated Protecting Groups

: 5'-Dimethoxytrityl-3'-phosphite amides of deoxynucleosides are synthesized. Phosphite/phosphate is protected by the 2,2,2-trichloro-1,1-dimethyl-ethyl (TCB) group, heterocyclic bases by the 2,2,2-trichloro-2,2-dimethyl-ethoxycarbonyl (TCBOC) group. Deoxyguanosine is also blocked by 6-O-trichloroethyl thus avoiding the difficulties observed with monoprotected guanine residues.