2001-P: Thermoneutrality Dissociates Glucose Tolerance from Insulin Sensitivity in Rats
2019
Thermoneutrality (TN) has been used to induce weight gain in rodent models of obesity. We hypothesized that TN would potentiate high-fat diet (HFD) impairment of vascular reactivity, diminish vascular mitochondrial function, and induce insulin resistance. Male rats aged 5-7 weeks were housed at room temperature (RT=23 C) or TN (29 C) and fed a low-fat diet (LFD) or HFD for 10-16 weeks. Aortic vasomotion and mitochondrial respiration (Oroboros O2k) were measured at the end of the study. Intraperitoneal glucose and insulin tolerance tests (IP-GTT and IP-ITT) were done at baseline and endpoint. Animals housed at TN had impaired vasodilation regardless of diet (effect of temperature, p Disclosure A.C. Keller: None. L. Knaub: None. S.E. Hull: None. R.L. Scalzo: None. L.A. Walker: None. J.E.B. Reusch: Board Member; Self; American Diabetes Association. Other Relationship; Self; Merck & Co., Inc. Funding U.S. Department of Veterans Affairs (BX003185-01A2, BX002046, CX001532); National Institutes of Health (5T32HL007171)
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