Micro Determination of Furosemide Pure and Some of its Pharmaceutical Preparations with Ammonium Hexanitratocerate (IV) Reagent

A new method has been developed for the micro determination of furosemide pure and some of its pharmaceutical preparations by using Ce(IV) reagent as oxidant. The method is simple, accurate, sensitive and gives reproducible results within + 1% error. Effects of different variables have been studied and SD & CV calculated. Recovery experiment is carried out by standard drug addition method. A probable reaction mechanism has also been suggested. Interference of various ions has been studied.