Regioselective synthesis of difluoroalkyl/perfluoroalkyl enones via Pd-catalyzed four-component carbonylative coupling reactions

The first example of Pd-catalyzed four-component carbonylative difluoroalkylation/perfluoroalkylation through the alkyne difunctionalization process is achieved. The reaction proceeds smoothly under mild conditions in the presence of 1 atm of CO at room temperature with good yields and E-selectivities. The utilization of CsF as an additive is vital to the success of the reaction.