Case Report: Exenatide Use During Pregnancy

Objective: To describe the effects on pregnancy outcomes of exposure to exenatide through the first trimester of pregnancy. Methods: A 35-year-old woman with type 2 diabetes mellitus, hypertension, infertility, oligomenorrhea, and morbid obesity, conceived spontaneously while taking multiple medications, including exenatide. The pregnancy was diagnosed incidentally at 14 weeks gestational age, and exenatide was discontinued at that time. Results: Fetal ultrasonography and echocardiography revealed no anomalies, and fetal growth was normal. Preeclampsia became superimposed on chronic hypertension at 38 weeks, and a complicated labor and delivery followed. No congenital anomalies were observed in the infant. Conclusions: In this one case, there were no congenital malformations or other adverse outcomes of pregnancy after exposure to exenatide through the first trimester. This case underscores the importance of counseling all women of reproductive age with preexisting diabetes regarding pregnancy.