Diaryl ether inhibitors of farnesyl-protein transferase.
2001
Abstract Imidazolemethyl diaryl ethers are potent inhibitors of farnesyl-protein transferase. The S N Ar displacement reaction used to prepare these diaryl ethers was amenable to rapid parallel synthesis of FPTase inhibitors. The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells.
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