Discovery of a small molecule inhibitor through interference with the gp120–CD4 interaction
2009
Abstract A series of piperazine derivatives were designed and synthesised as gp120–CD4 inhibitors. SAR studies led to the discovery of potent inhibitors in a cell based anti viral assay represented by compounds 9 and 28 . The rat pharmacokinetic and antiviral profiles of selected compounds are also presented.
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