Tributylphosphine as a superior catalyst for the α-C-addition of 1,3-dicarbonyl compounds to electron-deficient alkynes

Abstract The present work describes an improved one pot access to α-( gem -difunctional) cinnamate esters and to conjugated 1,3-diketones exploiting the addition of 1,3-diketones, β-keto esters and malonates to alkynoates catalyzed by phosphines. Among the catalysts, n Bu 3 P was found as one of the most effective allowing the reaction to proceed in milder conditions and in a more general manner than with other phosphines.