P-198 SPARC and TNF-α contribute significantly to erythroid failure in MDS with 5q deletion and influence considerably the efficacy of lenalidomide

G. Buesche1, A. Giagounidis2, O. Bock3, H. Teoman3, G. Gohring4, B. Schlegelberger4, S. Dieck3, A. Ganser5, A. List6, J.M. Bennett7, C. Aul8, H.H. Kreipe3. 1Department of Pathology, Hannover Medical School, Hannover, Germany; 2Department of Oncology Hematology and Palliative Treatment, Marienhospital, Dusseldorf, Germany; 3Department of Pathology, Hannover Medical School, Hannover, Germany; 4Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany; 5Department of Hematology Hemostasis Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany; 6Department of Interdisciplinary Oncology, University of South Florida, Tampa FL, USA; 7Cancer Center, University of Rochester, Rochester NY, USA; 8Department 2 Oncology and Hematology, St. Johannes Clinic, Duisburg, Germany