INVESTIGATION OF METAL IONS INFLUENCE ON LYSOZYME ACTIVITY BY THE QSAR ANALYSIS METHOD

The influence of 16 metal chlorides on lysozyme hydrolytic activity was studied. All cations, as it was shown, depresses lysozyme activity, besides the most significant influence exerts Al3+-, La3+-, Fe2+- and Li+- ions, inhibiting the enzyme activity on 64–85.7% in concentration of 5 mmol/ dm3. For the first time, by the QSAR analysis method, the three parametric model was obtained, using, as descriptors, the Pauling’s electronegativity, entropy and enthalpy of metal ions in aqueous solution, describing the influence of a wide range of metal chlorides on lysozyme activity.