Current progress in a adipocytokine-zinc-α 2-glycoprotein

Zinc-α2-glycoprotein(ZAG) is a soluble glycoprotein,present widely in the human body,is a member of the class I major histocompatibility complex family.ZAG is considered as a potential biomarkers of different types of carcinomas.Due to its high homology of amino acid sequence with lipid mobilization factor,it is considered as a novel adipokine.ZAG expression is regulated by different types of factors,can play important functions in the human body.ZAG stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers.This article will discuss mostly knowledge on the ZAG gene structure,distribution and function.