ROCK2 regulates TGF-β-induced expression of CTGF and profibrotic genes via NF-κB and cytoskeleton dynamics in the mesangial cells

The small GTPase Rho and its effector Rho-kinase are involved in the pathogenesis of diabetic kidney disease. Rho-kinase has two isoforms, ROCK1 and ROCK2. However, it remains unclear which is main...