Bf Types of HLA Haplotyped Individuals in an Isolated Newfoundland Population

Five hundred and fourteen individuals from an isolated Newfoundland population have been typed and haplotyped for HLA and Factor B (Bf locus). The Bf gene frequencies were: S 0.704, F 0.226, F1 0.052 and S1 0.018. Tracing the haplotypes backwards on the various pedigrees it was shown that 202 HLA/Bf haplotypes had been introduced into the study population. Some HLA alleles always appeared in association with particular Bf alleles and vice versa. Bf S1 had entered the population four times, always with HLA—A9, B12. Bf F1 had entered three times, always with HLA—B18. There were 17 entries of HLA—Al, B8 that had given rise to the 78 such haplotypes that were now present in the population; all were Bf S. There were 68 family units informative for Bf. They accounted for 240 children and 304 informative meioses. There were three recombinants in the HLA region but none could be shown to have occurred between the HLA—B and Bf loci.